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Reactions tend to be localized to application areas

These include serious infection, uremia or renal failure, drugs with bone marrow suppression properties (e.g., chloramphenicol), or concurrent undiagnosed folic acid or iron deficiency anemia

Retatrutide alone reached up to 24.2 percent average loss at 48 weeks in Phase 2, and Cagrilintide adds a satiety pathway shown to push combination numbers higher than a GLP-1 drug alone

Investigated for its ability to restore retinal function in degenerative conditions like Retinitis Pigmentosa

It is also banned by the World Anti-Doping Agency, meaning competitive athletes cannot use it without risking a positive drug test and sanctions