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This review explores the multiple mechanisms through which metformin exerts its antitumor effects, focusing on signaling pathways such as AMPK/mTOR, ferroptosis, autophagy, apoptosis and chloride ion channels (CLIC1)

Similarly, the dexamethasone cohort comprised patients who received drugs belonging to ATC code H02AB02 (Supplementary Table S1), and the patients who received dexamethasone for only topical usage were excluded

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Cancer treatment including antioxidants must be approached with caution to prevent the attenuation of oxidative mechanisms used in treatments such as chemotherapy and radiation therapy

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