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A 2022 clinical trial found semaglutide users lost an average of 15 pounds over 68 weeks, compared to 2-3 pounds in metformin-only groups

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The alpha-glucosidase inhibitory and GLP-1 pathway effects of the formulation may augment the glycaemic effects of antidiabetic medications, potentially increasing the risk of hypoglycaemia in sensitive individuals

If needed, a stool softener like docusate or osmotic laxative like miralax can be used safely alongside semaglutide