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So Yoon Kwon 1 , Jun Sung Moon 2 Endocrinology and Metabolism 2025;40(2):161-173

(4) In the SLZ + AA group, rats were used as the standard group

However, the former health store manager became unwell within hours and eventually went to hospital later after red welts developed all over her skin and left her in so much pain she thought she was 'going to die'

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There is also discussion in the same Medical News Today article that standard trials escalate doses monthly mainly to optimize effect under defined trial conditions, but that in real-world practice, individuals differ widely in sensitivity, metabolism, side effect profile, etc