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The effect of vitamin E on GPXs activity dlAlphatocopherol (vitamin E) also is an antioxidant, but it is different from selenium acting on GPX directly, vitamin E plays its antioxidant function through combining free radical, named chainbreaking reaction. Vitamin E was considered to be the first line of defense against lipid peroxidation and free oxygen radicals that might suppress the enzymes, such as GPX

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