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"Specifically, PDA encourages the use of the term 'drug substance' in place of 'active pharmaceutical ingredient (API)' as defined in ICHs harmonized tripartite guideline ICH Q6B Specifications: Test Procedures and Acceptance Criteria for Biotechnological/Biological Products," said PDA

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Besides the importance of iron and proteins involved in iron metabolism for multiple cellular functions, iron is tightly connected to the production of reactive oxygen species (ROS) and can lead to cell death when in excess ( Figure 1 In this review, we will first give an overview of the molecular basis of iron metabolism and its role in hematopoiesis

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