Despite years of clinical experience in diabetes and obesity, predicting responders to GLP-1RAs remains imprecise, closer to tossing a coin than true precision medicine (224, 226)
Notably, all participants started with very high ICP (mean ~ 30.6 cmCSF), so a 56 cmCSF reduction was felt to be clinically meaningful (roughly 1520% reduction)
Br J Pharmacol 179(4):659676 Hernandez AF, Green JB, Janmohamed S, DAgostino Sr RB, Granger CB, Jones NP, et al (2018) Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
If you have two copies of the C677T gene mutation or one copy of both the C677T and A1298C variants, you may have increased homocysteine levels
(Note: Its not clear what she meant by FDA pharmacies. The type of compounding pharmacy that the company uses is regulated by state boards of pharmacy, not the FDA.) As far as safety was concerned, the provider told me that people with cancer or who are breastfeeding shouldnt take peptides, and that I might have some soreness at the injection site