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IL-1Ra knockout in mice led to accelerated IDD, represented by decreased proteoglycan, disrupted collagen structure, increased matrix-degrading enzymes, including MMP3, MMP7, and ADAMTS4, 144 and a higher histological grade of degeneration

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10.1007/s11064-020-03058-3 95 SoltaniM.Hosseinzadeh-AttarM

Low Brain Folate in Autism, Seizures, and Neurological Disorders: Why Its Overlooked and How to Treat It Folate is critical for brain development, neurotransmitter production, and neuroprotection

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