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Despite the demonstrable importance of surveillance of lean mass during testing of obesity drug candidates, it is common for only fat mass loss or total body weight loss to be measured or presented in pre-clinical and early clinical trials

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As chylomicrons circulate in the vasculature, fatty acids are removed from the TG fraction through the action of endothelial cellassociated lipoprotein lipase (LPL)

Campbell JE, Mller TD, Finan B, DiMarchi RD, Tschp MH, DAlessio DA

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