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Despite the abundance of clinical data on the tumor-ablating effects of LITT, the biological mechanisms underlying the increased permeability of BBB caused by LITT are mostly unknown

With PT-141 (bremelanotide) specifically, the most commonly reported side effects include nausea, facial flushing, and mild increases in blood pressure

Glutathione injections minimize the damage to the colon for patients with ulcerative colitis

However, evaluation of the intestinal barrier in clinical studies is usually limited to the assessment of the paracellular permeability