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Nat Neurosci 27 , 421432 (2024)

Complementary Mechanisms When combined, these compounds create a multi-faceted approach to NO enhancement: Increased Substrate Availability - As described above, L-citrulline effectively raises plasma L-arginine levels, providing more raw material for nitric oxide synthase (NOS) enzymes to produce NO

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Schisandrin A also modulated autophagy and inflammation in these models: it inhibited excessive oxidative and inflammatory responses (for example, by reducing markers of lipid peroxidation and suppressing microglial activation) and helped normalize autophagy-related proteins that are disrupted in PD (59)

methylene tetrahydrofolate reductase, SHMT