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Aging (Albany NY) 2019;11, 771782, doi: Zhang, X

Take 1 to 2 capsules three times a day with food, or a dedicated dose 30 to 60 minutes before bed if sleep is the priority

And by the same token, if theres issues in methylation anywhere, not just MTHFR, but and the whole folate methionine cycle, were gonna see a compromised level of methyl donors being produced, which means histamine and methyltransferase doesnt have the conjugates to be able to clear histamine in the first place, so it is a bit of a wicked web to go down

Doses of pyridoxine as low as 5-10 mg can antagonize levodopas effect if carbidopa is not present, so caution is warranted and any supplemental B beyond the nutritional dose should be under medical guidance

10.3390/gels7030096 68 LeeM.YangC.SongG.LimW