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Each component addresses a different rate-limiting step in hepatic fat export: methionine provides substrate for methylation reactions, inositol enhances insulin receptor sensitivity, choline supports lipid packaging, and B12 keeps the methylation cycle running

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The system was solvated in a box (95 95 146 ) with TIP3P waters and 0.15 M NaCl, including 241 lipid molecules, 26064 water molecules, 77 chloride ions, and 73 sodium ions, for a total of 117,175 atoms