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Clinical Evidence Supporting Tirzepatide Use in Non-Diabetic Weight Loss The SURMOUNT-1 trial enrolled 2,539 non-diabetic adults with obesity and found that tirzepatide produced dose-dependent weight loss ranging from 15% at the 5 mg dose to 21% at the 15 mg dose, compared to 3% with placebo over 72 weeks

Cardiorenal protection with SGLT2 inhibitors in patients with diabetes mellitus: from biomarkers to clinical outcomes in heart failure and diabetic kidney disease

Gradual tapering over 48 weeks is safer and more effective than abrupt discontinuation