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GLP-1 injections do not directly interact with levothyroxine, but the slowed gastric emptying caused by GLP-1 may reduce levothyroxine bioavailability if taken too close together

Recently, the introduction of highly effective glucagon-like peptide-1 (GLP-1) receptor agonists has led to increased utilization of obesity medications in this population

This safety profile in animal models provides some reassurance about the compounds fundamental tolerability, though extrapolation to humans requires appropriate caution