Secretome engineering is an emerging frontier: PD-MSCs primed to secrete high hepatocyte-growth-factor engage Wnt/-catenin signalling to tighten endothelial barriers and foster follicular growth [183], while an estrogen-responsive PD-MSC secretome rescues cyclophosphamide-induced POI, restores circadian clock genes and curbs granulosa-cell apoptosis, suggesting cell-free formulations could combine ovarian repair with systemic chronoprotection [20]
doi:10.1177/1753465812437563 Tse HN, Raiteri L, Wong KY, et al
This study examined the hypothesis that GSH-deficiency induces epigenetic alterations of VD metabolism genes, which can reduce the circulating 25(OH)VD 3 levels in obesity
This comprehensive, multi-layered approach guarantees a sharply sculpted result that one-off treatments simply cannot match
Engineering T-lymphocytes to express factors important for modulating an inflammatory response (such as IL-4, IL-10, and TGF-), to express neurotrophic factors (BDNF, GDNF, IGF-1), or to silence pro-inflammatory factors such as TNF- and especially Nox2 could even further stimulate neuroprotection (Fig
