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Depletion of GSH due to intensified oxidative stress or the action of inhibitors significantly reduces the ability of GPX4 to counteract lipid peroxidation, leading to increased lipid peroxides and subsequent ferroptosis (151)

SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors

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One pathway creates NAPQIa reactive compound that needs to be neutralized quickly

[00:28:59] Emily Field: I had say the third strategy that we need to talk about today is the appropriate dose, progression, and open communication with your prescriber