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An expired supplement is unlikely to be poisonous, but it is also unlikely to provide the full nutritional support promised on the packaging

There are specific, documented cases where a qualified dermatologist might consider it: severe and resistant pigmentation conditions, including certain presentations of melasma that have not responded adequately to topical treatments, oral supplements, and professional procedures over an extended period

Moreover, natural antioxidants such as crocetin increase the bodys antioxidant capacity by activating the Nrf2/ARE pathway and promoting gene expression of antioxidant enzymes

10.1111/j.1469-8137.2006.01643.x 114 SairamK.RaoK

stimulates detox system