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It was found that while inhibition of PGE 1 further increased the levels of certain cytokines in serum and peritoneal fluid [45], inhibition of PGE 2 reversed these values toward that of control [46]

Oxidative stress and Mitochondrial Dysfunction Glutathione Peroxidases (GPx) Glutathione peroxidase (GPx) enzymes are essential selenoproteins involved in the antioxidant defense and have been extensively investigated in pre-clinical models, which have been reviewed elsewhere [63]