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Scalability of production and cost-effectiveness are also major concerns, alongside potential immunogenicity, and safety issues, particularly with EVs derived from allogeneic sources

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Unregulated peptides are sourced primarily from Chinese manufacturers, linking drug regulation to cross-border supply chains and enforcement challenges

Because the skin's natural turnover process takes about 30 days, it takes time for the internal changes in melanin production to appear on the surface

GHK-Cu peptide is also apparently active as a matrikine, potentially recruiting repair-associated cells and promoting angiogenesis