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Rights and permissions About this article Cite this article Lucero, M.Y., Chan, J
While polygenic risk scores (PRS) address part of this architecture by aggregating validated risk alleles from GWAS, the proposed workflow further considers the potential cumulative burden of variants typically deemed benign, aiming to bridge the gap between population-level risk estimation and individualized interpretation (Torkamani et al., 2018)
Geislers team also examined whether GLP-1 drugs act directly on DBI-producing cells
Chronic cocaine exposure has been linked to an increased risk of Parkinsons disease, as it promotes -synuclein overexpression in dopamine neurons, causing resting tremors and neurotoxic damage (Mash et al., 2003)
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