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For many people, the symptoms are mild and temporary, especially during the first weeks of treatment or after dose increases

Although not traditionally believed to be a CYP450 enzyme involved in paracetamol oxidation, it may be that possession of this allele allows CYP3A5 to use paracetamol as a substrate and hence enhance its bioactivation with resultant liver injury

NAD+ also helps "recharge" antioxidants like glutathione, creating a synergistic effect in the body

When combined with the effects of anesthesia, which itself can trigger nausea and vomiting, this creates additional surgical risk

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