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Furthermore, CHAC1 negatively regulates the NOTCH1 receptor, a key player in determining cell fate, particularly in neuronal stem cells, affecting their development and differentiation ( 2.1 CHAC1 upregulation under arsenite stress and amino acid depletion As a stress-responsive protein, CHAC1 is critically involved in the cellular stress response

[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Sau A., Pellizzari Tregno F., Valentino F., Federici G., Caccuri A.M

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Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps

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