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Causes of the condition are not fully defined, but at least part of the problem can be contributed to an infection in honey bee guts by the fungus Nosema ceranae

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Liver/Kidney/CYP450: High-dose systemic copper chelate therapy requires strict monitoring of ceruloplasmin and unbound serum copper to prevent heavy metal toxicity or Wilson-like hepatic accumulation

have pre-existing lung disease, have used medications that are known to cause toxicity to your lungs, medicines called colony-stimulating factors, or have previously received radiation therapy