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GLP-1R expressed in the nucleus tractus solitarius signals to suppress appetite, delay gastric emptying and reduce body weight, and this is proposed to be mediated through PKA, decreasing phosphorylation of AMPK (89, 110)

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The outcome of this study, following the delivery of the cell culture with Epithalon, was that the peptide appeared to induce activation of the ribosomal genes and decondensation of the heterochromatin

B.PaulsonK.SharmaV.DyckJ

EMBO Rep 6: 2832 Frand AR, Kaiser CA (1998) The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum