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The three FDA-approved injection sites are the abdomen, outer thigh, and upper arm, each offering similar absorption rates when proper injection depth is maintained

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Additional refinements to its structure to limit both phase 1 and phase 2 hepatic metabolism and first pass clearance, to reduce metabolism by gastric enzymes and enhance oral bioavailability, and to diminish polar surface area and overall size to facilitate BBB penetrability are currently in progress

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