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On the other hand, ablating the PVH or deleting GLP-1Rs in this brain region does not prevent the inhibitory effects on food intake and body weight of chronic systemic liraglutide [126, 130] or exendin-4 [128, 131]

Iron supplementation worsens neurodegeneration in HD mice by reducing striatal volume (van Bergen et al., 2016)

However, the success of LT can be significantly influenced by various pre- and post-transplant factors, among which cigarette smoking has emerged as a critical determinant of patient and graft outcomes

Although these therapies provide significant clinical benefits, substantial unmet needs remain, creating opportunities for further innovation

& Bataille, D