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Weight loss is also significant, with participants losing an average of 15% to 20% of body weight at higher doses of tirzepatide

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Secondary outcomes encompass MACEs, including stroke (either ischemic or hemorrhagic), acute myocardial infarction (AMI), cardiac arrest, cardiogenic shock or death, as well as major adverse kidney events (MAKEs), which is defined as a composite of dialysis dependence, an eGFR less than 15 mL/min/1.73 m, or death

The Phase 3 TRIUMPH-4 population had knee osteoarthritis as a comorbidity, which may influence tolerability