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Maack C, Lehrke M, Backs J, Heinzel FR, Hulot JS, Marx N, Paulus WJ, Rossignol P, Taegtmeyer H, Bauersachs J, et al

In addition, unlike studies in human volunteers, which have historically comprised the majority of fMRI research [62] the specific mechanisms that alter functional connectivity in GLP-1R KO mice versus WT mice can be investigated with the full toolset available to rodent neuroscience

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We dont yet thoroughly understand all of the effects of either Ipamorelin or CJC-1295

Sample size calculation The sample size calculation was based on the assumptions of a mean difference in the primary endpoint CDR-SB score of 0.44 points (relating to a 20% difference between semaglutide and placebo when assuming a mean increase in the placebo arm of 2.2 points), standard deviation of 2.6 points, and one-sided significance level of 0.025