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Treating insomnia with high risk of depression using therapist-guided digital cognitive, behavioral, and circadian rhythm support interventions to prevent worsening of depressive symptoms: a randomized controlled trial

This includes those with recent weight gain from injury, surgery, pregnancy, or menopause, as well as individuals who have struggled with excess weight for much of their life

Tissues were fixed and processed, then stained with specific primary antibodies

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We used a modified Cochrane risk of bias tool to assess the risk of bias, used GRADE to assess the certainty of evidence, and used the Credibility of Effect Modification Analyses (ICEMAN) tool to assess the credibility of any apparent subgroup effect