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Neurological symptoms are particularly associated with vitamin B12 deficiency and can be serious

The free tripeptide chelates a single Cu(II) ion through its N-terminal amine, the deprotonated glycyl amide nitrogen and the histidine imidazole, giving the square-planar complex responsible for the deep blue colour of a reconstituted ghkcu solution

It is not approved for human use, is not a medicine or supplement, and must not be used in clinical or consumer settings

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Stress management becomes part of the treatment for conditions like rosacea