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B12 shots are often recommended when there is a known absorption issue with B12 through the digestive system

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[5] Use of Lipo-C Injection is contraindicated in patients with known hypersensitivity to methionine, choline salts, carnitine, dexpanthenol, or any formulation excipients, as well as in individuals with severe hepatic failure in whom augmented methionine intake could precipitate hypermethioninemia and encephalopathy