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Taking into account the high rate of demand and energy consumption of the brain, the majority of mitochondrial mutations can affect the functioning of the CNS and have been associated with neurodegenerative diseases (Angelova and Abramov, 2018)

Stable expression of shRNA or cDNAs were screened for 4 weeks with puromycin (2.0 mg/mL)

Abbreviations CARN: L- carnitine MD: Mildronate MTX: Methotrexate AMPK1: Adenosine monophosphate-activated protein kinase ACC-1: Acetyl-CoA carboxylase-1 ATP: Adenosine triphosphate BUN: Blood urea nitrogen AST: Aspartate aminotransferase ALT: Alanine aminotransferase References Hanoodi M, Mittal M