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You have adopted the calorie hypothesis

Nauck MA, Homberger E, Siegel EG, Allen RC, Eaton RP, Ebert R, et al

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It should also be taken into account that DIO mice show changes in the abundance of Lachnospiraceae depending on the dietary fat source 77 , and suppressed high-fat diet intake by liraglutide and GUB09-145 treatment could therefore potentially have impacted the composition of this bacterial family