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By reducing excessive Ca 2+ influx (a trigger of cell death) and preventing the release of pro-apoptotic factors like cytochrome c from mitochondria, schisandrins effectively decreased apoptotic cell death in this model (58)

In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%)

Topiramate may cause a severe rash with blisters and peeling skin, especially around the mouth, nose, eyes, and genitals (Stevens-Johnson syndrome)

Symptoms suggesting thyroid abnormalitiesincluding a neck mass, persistent hoarseness, dysphagia, or dyspnearequire evaluation, given the medication's boxed warning regarding thyroid C-cell tumors observed in rodent studies (though human relevance remains uncertain)