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Gut microbiome-generated metabolites, such as colonic acid, D-lactic acid, D amino acids, and methyl metabolites, can pass the bloodbrain barrier and modulate neuronal behavior

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TGR5 and bile acid TGR5 is a member of the G-protein-coupled receptor superfamily and is expressed in various tissues, including pancreas Cells, endocrine cells in the small intestine, thyroid, brown adipose tissue, cardiomyocytes, and macrophages [11, 13]

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