glutathione reporter SDHB deficiency activated NRF2-driven synthetic pathway Real-time monitoring of glutathione in

Drug Metab Dispos.32:281290 (2004).Guillemette C

Protective and toxic roles of dopamine in Parkinson's disease

Beyond its conventional malate-aspartate shuttle function, GOT2 also enhances the transcriptional activity of the PPAR through direct fatty acid binding

By activating these receptors in the brains satiety centers (like the area postrema), it promotes feelings of fullness, reduces food intake, and helps stabilize post-meal blood sugar spikes, making it a promising candidate for weight management, particularly in combination with the GLP-1 receptor agonist semaglutide (marketed as CagriSema)

Pearson correlations were also calculated between metabolite levels and dimensional scores of ASD and ADHD symptom severity (respectively Conners and ADOS for the ASD group only)