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Here, we show that hepsin deficiency in mice exacerbates acetaminophen toxicity compared to wild-type mice, leading to more severe liver pathology, elevated oxidative stress, and greater mortality within 6 h after exposure

The increase in plasma homocysteine concentration in this study was marginal at 0.6 mol/L, and the causal relationship between hyperhomocysteinemia and adverse health outcomes is still uncertain 40,41

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