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We have shown that multiple types of cytotoxic immune cells found in acute lesions, including T cells, activated NK cells 37 , CD56 + NKG2C + CD4 + T cells 38 , and CD4 + Th17 cells 39 can mediate non-MHC restricted cell-cell contact lethal injury of human adult brain-derived mature OLs in vitro (Fig

A., Fasold, M

Deficiency in NUDT15 leads to relatively higher TGTP formation, which hypothetically promotes the formation of DNA-TG and inhibition of Rac1 [65]

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