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Patients should have optimized behavioral factors, including dietary adherence, physical activity, and psychological support, as medication is not a substitute for lifestyle modification

The latent form of TGF-1 is bound by ECM structure, however, TGF-1 signaling is swayed by its binding substrate, e.g., binding to Fibulin 4 decreases TGF-1 signaling 42 , while binding to Fibulin 2 enhances TGF-1 43