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Blockade of IL-7 ameliorates joint inflammation by reducing T cells trafficking and proinflammatory factors like TNF-, IL-1, IL-6, and MMPs (77)

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To investigate the impact of shifting from cystine-driven to GSH-driven cysteine supply in cancer cells in an unbiased manner, we performed a multifunctional approach to pharmacological screening (MAPS) with a library of 240 metabolic inhibitors (Fig

Also, both mutant and WT SOD1 produce cytotoxic levels of H 2 O 2 via a cysteine redox regulation system (Bakavayev et al., G93A mice show significantly increased protein carbonyl levels in the spinal cord, including elevated carbonylation of mutant SOD1, which has been linked to motor neuron degeneration (Poon et al., 2005)