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They are also believed to have a role in improving the energy level and immune system function, although strong clinical evidence supporting these effects remains limited

It is reported that phosphorylation of SMAD2/3 increased TGF-1-induced fibroblasts from PD plaques, and that SMAD7 may have an antagonistic role on TGF-1 signaling and subsequently limit the response of fibroblasts to TGF-1 in PD (Herati and Pastuszak, 2016)