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(2015) 13:e1002202

NAC has free radical scavenging activity both in vivo [19] and in vitro [20, 21]

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Common causes of injection discomfort: Needle penetration through pain-sensitive dermis Rapid injection speed causing tissue distension Cold medication temperature Medication pH and formulation characteristics Injection into areas with less subcutaneous fat Reusing injection sites without adequate rotation Muscle tension at the injection site can also amplify pain perception