The findings deliver early evidence that semaglutide may offer a dual benefit, targeting obesity and key reproductive challenges associated with the condition, including irregular menstruation and impaired fertility. Clare Thompson, MBBS, BSc, nMRCGP Separately, a review of five randomized controlled trials presented at ENDO 2026 found that GLP-1 drugs, such as semaglutide and liraglutide, do not appear to harm male fertility and may even improve testosterone levels and sperm quality in some men with obesity
For some patients, the act of injecting themselves with medication is unpleasant, which can create a negative association with the entire treatment
The GIP receptor component appears to enhance the insulinotropic effect of GLP-1 activation while simultaneously reducing adipose tissue inflammation and improving lipid metabolism
Your provider can review your labs, evaluate possible contraindications, monitor your response, and adjust your protocol when needed
The clinical literature reports typical adult ranges and FDA-approved labeling exists where applicable, but a fixed public chart cannot account for the individual variables a clinician weighs