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It is also generally well tolerated by most patients without significant side effects or risks associated with long-term use

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Research suggests that it is widely used to study melanogenesis, melanocortin receptor pharmacology, neuroendocrine and metabolic pathways, and the safety profiles associated with unregulated tanning-agent use in both preclinical models and clinical case studies, without any approved therapeutic indications

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For gene expression analysis, the sequences of forward and reverse primers used to amply chicken gss , gsr , ggt , sod2, and housekeeping gene -actin were designed by NCBI blast (Table 1)