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Regulation of differentiation potential of human mesenchymal stem cells by intracytoplasmic delivery of coactivator-associated arginine methyltransferase 1 protein using cell-penetrating peptide
Add diluent slowly down the side of the vial rather than directly onto the peptide powder to prevent foaming and incomplete dissolution
Escalation phase breakdown The standard protocol starts low and increases every four weeks to minimize gastrointestinal side effects that rapid dose escalation can cause
Mistake 1: shaking the vial We covered this, but it bears repeating because it is the single most common error
Low suspicion for disseminated intravascular coagulation (DIC) with largely unremarkable coagulation panel (PT/INR 15.9 seconds/1.3, aPTT 32.9 seconds, and fibrinogen 366 mg/dL), thrombotic thrombocytopenic purpura (TTP) with normal ADAMTS13 activity 86% and antibody levels 3, and other forms of thrombotic microangiopathy (TMA) with no significant schistocytes on peripheral blood smear, negative direct anti-globuin test (DAT), normal complement levels and kidney function
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