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Insulin use was reported for 34.6% of patients 180 days before the index date, and 62.1% had used either one or two medications in a GLD class other than GLP-1 RA, most often metformin (50.4%)

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While diet and exercise are important steps, most patients don't achieve their desired treatment goals with only diet and exercise. Lilly plans to begin the process of submitting a rolling new drug application for this indication soon

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A systematic review and meta-analysis synthesizing evidence from CVOTs with a total of 56,004 participants did not identify an increased risk of HF in such patients (reducing all-cause mortality by 12% and hospital admission for HF by 9%) [60]