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A number of conditions can lead to a lack of folate or vitamin B12

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Massive acetaminophen poisoning Massive poisoning may be defined as patients with any of the following: Clinical presentation A patient with high-risk ingestion may be critically ill early following the overdose and before hepatic failure develops due to parent-compound toxicity *

Elderly subjects exhibit a 94.6% lower glutathione concentration compared to younger adults, making efficient replenishment critical