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Researchers are examining whether altered NNMT activity affects nicotinamide metabolism, NAD-related pathways, methyl-donor balance and selected metabolic processes

Notably, experiments in mice showed that a high-fat diet or clock-disrupting conditions alter microbial rhythms, which then contributes to hepatic circadian clock dysfunction and obesity

BMB Rep 37(6):749752 Rahimi K, Ezzati Givi M, Rezaie A, Hekmatmanesh M, Shaker Ardakani Y (2024) The protective effects of Gamma-linolenic acid against indomethacin-induced gastric ulcer in rats

Despite the availability of numerous FBXO22-recruiting degraders, the structure of FBXO22 recruiting a neosubstrate is not currently available