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Nature , 2022, 604(7907): 714-722

PI3K/Akt/mTOR Signaling The two primary signaling pathways activated by IGF-1 DES through IGF1R are the PI3K/Akt/mTOR axis and the Ras/Raf/MEK/ERK MAPK cascade, both of which drive anabolic processes, cell survival, proliferation, and metabolic reprogramming

As illustrated in Figure 5, our meta-analysis revealed no statistically significant difference in dropout rates between the curcumin and placebo groups (OR = 0.95, 95% CI 0.66 to 1.38, I 2 = 0%, p = 0.80)

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